Date Updated: 07/15/2021


A nuclear stress test uses a small amount of radioactive material (tracer) and an imaging machine to create pictures showing the blood flow to your heart. The test measures blood flow while you are at rest and during activity, showing areas with poor blood flow or damage in your heart.

A nuclear stress test is one of several types of stress tests. The radiotracer used during a nuclear stress test helps your doctor determine your risk of a heart attack or other cardiac event if you have coronary artery disease. A nuclear stress test may be done after a regular exercise stress test to get more information about your heart, or it may be the first stress test used.

The test is done using a positron emission technology (PET) scanner or single photo emission computed tomography (SPECT) scanner. A nuclear stress test may also be called a myocardial perfusion imaging (MPI) study, cardiac PET study or cardiac SPECT study.

Why it's done

You may need a nuclear stress test if you have signs or symptoms of heart disease such as chest pain or shortness of breath. A nuclear stress test may also be used to guide your treatment if you've been diagnosed with a heart condition. Your doctor may recommend a nuclear stress test to:

  • Diagnose coronary artery disease. Your coronary arteries are the major blood vessels that supply your heart with blood, oxygen and nutrients. Coronary artery disease develops when these arteries become damaged or diseased — usually due to a buildup of deposits containing cholesterol and other substances (plaques).

    If you have symptoms such as chest pain or shortness of breath, a nuclear stress test can help determine if you have coronary artery disease and how severe the condition is.

  • Determine a treatment plan. If you have coronary artery disease, a nuclear stress test can tell your doctor how well treatment is working. The test also helps your doctor develop the right treatment for you by determining how much exercise your heart can handle.


A nuclear stress test is generally safe. Complications are rare. As with any medical procedure, there is a risk of complications, which may include:

  • Abnormal heart rhythms (arrhythmias). Arrhythmias that occur during a stress test usually go away shortly after you stop exercising or the medication wears off. Life-threatening arrhythmias are rare.
  • Heart attack. Although extremely rare, it's possible that a nuclear stress test could cause a heart attack.
  • Low blood pressure. Blood pressure may drop during or immediately after exercise, possibly causing you to feel dizzy or faint. The problem should go away after you stop exercising.
  • Dizziness or chest pain. These symptoms can occur during a nuclear stress test. Some people also have nausea, shakiness, headache, flushing, shortness of breath and anxiety during the stress test. These signs and symptoms are usually mild and brief, but tell your doctor if they occur.

How you prepare

Your doctor will give you specific instructions on how to prepare for your nuclear stress test.

Food and medications

You may be asked not to eat, drink or smoke for a period of time before a nuclear stress test. You may need to avoid caffeine the day before and the day of the test.

Ask your doctor if it's safe for you to continue taking all of your prescription and over-the-counter medications before the test, because they might interfere with certain stress tests.

If you use an inhaler for asthma or other breathing problems, bring it to the test. Make sure your doctor and the health care team member monitoring your stress test know that you use an inhaler.

Clothing and personal items

Wear or bring comfortable clothes and walking shoes. Don't apply oil, lotion or cream to your skin on the day of your nuclear stress test.

What you can expect

A nuclear stress test involves injecting a radioactive tracer, then taking two sets of images of your heart — one while you're at rest and another after exercise.

A nuclear stress test is done along with an exercise stress test, in which you walk on a treadmill. If you aren't able to exercise, you'll receive a drug through an IV that mimics exercise by increasing blood flow to your heart.

A nuclear stress test can take two or more hours, depending on the radioactive tracer and imaging tests used.

Before a nuclear stress test

Your doctor will ask you some questions about your medical history and how often and actively you exercise. This helps determine the amount of exercise that's best for you during the test. Your doctor will also listen to your heart and lungs for any problems that might affect your test results.

Why it's done

During a nuclear stress test

Before you start the test, a nurse or technician inserts an IV line into your arm and injects the radiotracer (also called a radiopharmaceutical).

The radiotracer may feel cold when it's first injected into your arm. It takes a few minutes for your heart cells to absorb the radiotracer. Once it does, you'll lie still on a table and have your first set of images taken while your heart is at rest.

Then, a nurse or technician will place sticky patches (electrodes) on your chest, legs and arms. Some areas may need to be shaved to help them stick. The electrodes have wires connected to an electrocardiogram (ECG or EKG) machine, which records the electrical signals that trigger your heartbeats. A cuff on your arm checks your blood pressure during the test. You may be asked to breathe into a tube during the test to show how well you're able to breathe during exercise.

If you can't exercise, your doctor will inject a medication into your IV line that increases blood flow to your heart. Possible side effects may be similar to those caused by exercise, such as flushing or shortness of breath. You might get a headache.

If your nuclear test is combined with a traditional exercise stress test, you'll be asked to walk on a treadmill or ride a stationary bike. You'll start slowly. The exercise gets more difficult as the test continues. You can use the railing on the treadmill for balance. Don't hang on tightly, as this may alter the results.

You'll continue exercising until your heart rate has reached a set target or you develop symptoms that don't allow you to continue, which may include:

  • Moderate to severe chest pain
  • Severe shortness of breath
  • Abnormally high or low blood pressure
  • An abnormal heart rhythm
  • Dizziness
  • Certain changes in your ECG

You and your doctor will discuss your safe limits for exercise. You can stop the test anytime you're too uncomfortable to continue.

You'll have another injection of radiotracer when your heart rate peaks after exercising. Then, you'll lie still on a table and have the second set of images taken. The radiotracer shows up on the images and highlights any areas of your heart that don't get enough blood flow.

Your doctor will compare the two sets of images taken to see how blood flows through your heart while you're at rest and under physical stress.

What you can expect

After a nuclear stress test

After you stop exercising, you might be asked to stand still for several seconds and then lie down for a short while with the monitors in place. Your doctor can watch for any problems as your heart rate and breathing return to normal.

When the test is complete, you may return to normal activities unless your doctor tells you otherwise. The radioactive tracer will naturally leave your body in your urine or stool. Drink plenty of water to help flush the tracer out of your system.


Your doctor will discuss your nuclear stress test results with you. Your results could show:

  • Normal blood flow during exercise and rest. You may not need further tests.
  • Normal blood flow during rest, but not during exercise. Part of your heart isn't receiving enough blood when you're exerting yourself. This might mean that you have one or more blocked arteries (coronary artery disease).
  • Low blood flow during rest and exercise. Part of your heart isn't getting enough blood at all times, which could be due to severe coronary artery disease or a previous heart attack.
  • Lack of blood flow in parts of your heart. Areas of your heart that don't show the radioactive tracer have damage from a heart attack.

If you don't have enough blood flow through your heart, you may need to have coronary angiography. This test looks directly at the blood vessels supplying your heart. If you have severe blockages, you may need an angioplasty and stent placement or open-heart surgery (coronary artery bypass).

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